The state of Indiana currently has 21 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Indianapolis, South Bend, Fort Wayne and Evansville.
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
NCT05929066
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: Brengle Family Medicine, Indianapolis, Indiana
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
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Patient Retrospective Outcomes (PRO)
NCT01550575
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/11/2024
Locations: Summit Research Institute, Fort Wayne, Indiana +1 locations
Conditions: Chronic Pain
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RELIEF - A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
NCT01719055
Recruiting
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Directions for Use - and - To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice
Gender:
All
Ages:
18 years and above
Trial Updated:
06/06/2024
Locations: Global Scientific Innovations - Advanced Pain Care Clinic, Evansville, Indiana +3 locations
Conditions: Pain
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QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
NCT03434392
Recruiting
Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic Pancreatitis (CP). QST uses a specific series of standardized stimulations to map the pain system. QST has the potential to change and improve the treatment paradigm for patients with CP and may eventually be able to predict response to invasive CP therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/05/2024
Locations: Indiana University Medical Center, Indianapolis, Indiana
Conditions: Chronic Pancreatitis, Chronic Pain
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Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
NCT04996628
Recruiting
Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/05/2024
Locations: Indiana University Medical Center, Indianapolis, Indiana
Conditions: Chronic Pancreatitis, Chronic Pain
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A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
NCT05740007
Recruiting
The aim of this study is to assess whether IW-3300 is safe and works for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). The main question the study aims to answer is whether IW-3300 helps bladder pain and other symptoms (for example, bladder burning, pressure and discomfort). Subjects will be assigned to receive either the study drug or placebo by chance.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/30/2024
Locations: First Urology PSC, Jeffersonville, Indiana
Conditions: Interstitial Cystitis, Bladder Pain Syndrome
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The Prevalence of Neuropathic Pain Pathophysiology Associated With Ankle Fracture
NCT06420141
Recruiting
This application addresses the Peer Reviewed Medical Research Program Investigator-Initiated Research Award FY21 W81XWH-22-CPMRP-IIRA area of Chronic Pain Management Research Program- The investigators will utilize subjects who have sustained ankle fractures and may develop chronic pain following bone union. No attempt will be made to affect the experimental outcome in the subjects. This study will adhere to a core set of standards for rigorous study design and reporting to maximize the reproduc... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/16/2024
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Neuropathic Pain
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Trial Readiness and Endpoint Assessment in LGMD R1
NCT05618080
Recruiting
This is a 24-month, observational study of 100 participants with Limb Girdle Muscular Dystrophy type R1, also known as CAPN3.
Gender:
All
Ages:
Between 12 years and 50 years
Trial Updated:
05/06/2024
Locations: The Community Health Clinic, Inc., Shipshewana, Indiana
Conditions: Calpain-3 Deficiency Limb Girdle Muscular Dystrophy Type 2A, Limb Girdle Muscular Dystrophy, Limb Girdle Muscular Dystrophy Type R1, LGMD2A
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Surgical Myomectomy Followed by Oral Myfembree Versus Standard of Care Trial (SOUL)
NCT05538689
Recruiting
In this project, the proposition is that the use of daily dosed Myfembree ( a combination of relugolix with estradiol and norethindrone acetate), FDA-approved medication to treat heavy menses fibroid-related symptoms, has the potential to delay the recurrence of fibroid symptoms, prolong the improved quality of life and delay the need for re-intervention after uterine sparing surgery versus the routine standard of care.
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of Chicago Schererville, Schererville, Indiana
Conditions: Metrorrhagia, Pelvic Pain, Menorrhagia, Leiomyoma
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Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
NCT06229470
Recruiting
The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/02/2024
Locations: Goodman Campbell Brain and Spine, Carmel, Indiana
Conditions: Chronic Pain
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Pre-Rehabilitation for Female Patients Undergoing Pelvic Radiotherapy
NCT06059586
Recruiting
The purpose of this study is to examine the feasibility of adding pre-rehabilitation pelvic health physical therapy to standard of care radiation therapy treatment plan for female patients who have been diagnosed with cervical, vaginal, vulvar, uterine, or anal cancer and are a candidate for curative pelvic radiation with external beam. Participants will receive education on using a vaginal dilator for use during treatment and complete questionnaires looking at pain and sexual function.
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: IU Health Schwarz Cancer Center, Carmel, Indiana
Conditions: Dyspareunia, Pelvic Pain, Sexual Dysfunction, Radiation Toxicity
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Integrative Medicine in Pain Management in Sickle Cell Disease
NCT05045820
Recruiting
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.
Gender:
All
Ages:
Between 14 years and 80 years
Trial Updated:
04/04/2024
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing, Magnetic Resonance Imaging, Circulating Biomarkers, Electroencephalography, Functional Near-infrared Spectroscopy
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